
Understanding the Difference Between CO2 and RF Microneedling
If you’re exploring skin rejuvenation treatments, chances are you’ve come across CO2 laser resurfacing and RF microneedling. Both offer incredible results—but they work differently, feel different, and suit different skin goals. At 112 West Medical Aesthetics and Wellness, we’re here to help you make an informed choice. RF microneedling vs CO2 laser
What Is CO2 Laser Resurfacing?
CO2 (carbon dioxide) laser resurfacing is a powerful treatment that uses focused light energy to remove the outer layers of damaged skin. According to the American Society of Plastic Surgeons, CO2 laser resurfacing has long been considered a gold standard for treating deep wrinkles and scars. It targets:
- Deep wrinkles
- Texture irregularities
- Scars (including acne and surgical scars)
- Sun damage and pigmentation
Ideal For:
- More advanced signs of aging
- Moderate to deep acne scarring
- Skin that can tolerate 5–10 days of social downtime
Benefits:
- Smoother, more even skin texture
- Significant collagen stimulation
- Noticeable results after one treatment
Downtime:
- 5 to 10 days of redness, peeling, and tightness
What Is RF Microneedling (VirtueRF)?
At 112 West, we use the Cartessa VirtueRF, a next-generation radiofrequency microneedling platform known for delivering customized, high-precision results. VirtueRF combines ultra-fine needles with radiofrequency energy to stimulate collagen production in the deeper layers of skin—without damaging the surface.
We also elevate every VirtueRF treatment with AnteAGE Exosomes, a powerful regenerative booster that enhances healing, reduces redness, and accelerates collagen and elastin production. These are included in every RF microneedling session at no extra cost, ensuring our clients experience optimized results and minimal downtime.
Ideal For:
- Early signs of aging or mild acne scarring
- Clients wanting minimal downtime
- Building collagen gently over time
Benefits:
- Firmer, tighter skin
- Reduced pore size and texture
- Enhanced recovery and glow with exosomes
- Gentle resurfacing with little to no peeling
Downtime:
- 24–72 hours of mild redness or swelling
- 24–72 hours of mild redness or swelling

CO2 vs. RF Microneedling: A Side-by-Side Look
Feature | CO2 Laser Resurfacing | RF Microneedling |
---|---|---|
Depth | Deep skin resurfacing | Targets deeper dermis without surface damage |
Results | Significant after one session | Cumulative over 3+ sessions |
Ideal For | Deep wrinkles, scars, texture | Mild to moderate skin laxity or fine lines |
Downtime | 5–10 days | 1–3 days |
Cost | Higher per session | More affordable per session, but often done in a series |
When Should I Book RF Microneedling vs. CO2 Laser?
If you’re preparing for a wedding or big event, RF microneedling is a great choice thanks to its short recovery window.
If you have time off during the holidays or want to reset your skin deeply after summer, a single CO2 laser session can deliver dramatic results.

✨ Curious which treatment is right for you?
We’re opening soon in Queen Creek! If you’re considering RF microneedling vs CO2 laser, now’s the perfect time to explore your options. Choosing between CO2 laser and RF microneedling depends on your skin goals, timeline, and tolerance for downtime. During your Laser & Skin Consultation at 112 West, we’ll assess your skin, talk about your lifestyle, and recommend a plan that delivers real results. Follow us on Instagram or join our email list to be the first to know when booking opens.
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Frequently Asked Questions
Q: Is RF microneedling or CO2 laser better for acne scars?
A: CO2 laser is generally more effective for deeper acne scars, while RF microneedling may be a better choice for mild texture and minimal downtime.
Q: Can I combine these treatments?
A: Yes — some clients benefit from alternating both treatments as part of a long-term plan. Our expert providers will help you decide.
Q: Does RF microneedling hurt less than CO2?
A: Most people find RF microneedling more comfortable with quicker recovery, but we offer numbing with both treatments for comfort.